Ontology highlight
ABSTRACT:
SUBMITTER: Shen X
PROVIDER: S-EPMC6981159 | biostudies-literature | 2020 Jan
REPOSITORIES: biostudies-literature
Shen Xingyu X Ting Chi P CP Xu Gong G Maimone Thomas J TJ
Nature communications 20200124 1
The bicyclo[3.3.1]nonane architecture is a privileged structural motif found in over 1000 natural products with relevance to neurodegenerative disease, bacterial and parasitic infection, and cancer among others. Despite disparate biosynthetic machinery, alkaloid, terpene, and polyketide-producing organisms have all evolved pathways to incorporate this carbocyclic ring system. Natural products of mixed polyketide/terpenoid origins (meroterpenes) are a particularly rich and important source of bio ...[more]