Unknown

Dataset Information

0

Carbazole Alkaloids from Clausena anisum-olens: Isolation, Characterization, and Anti-HIV Evaluation.


ABSTRACT: Two new carbazole alkaloids (1,2) and six known carbazole alkaloids (3-8) were isolated from Clausena anisum-olens. Their structures were elucidated based on extensive spectroscopic analysis. All isolated compounds (1-8) were evaluated for their anti-HIV effects on virus replication in MT-4 lymphocytes infected by HIV-1NL4-3 Nanoluc-sec virus, and new carbazole alkaloid 1 exhibited anti-HIV activity with an EC50 value of 2.4 ?g/mL and SI of 7.1.

SUBMITTER: Yang JH 

PROVIDER: S-EPMC6983056 | biostudies-literature | 2019 Dec

REPOSITORIES: biostudies-literature

altmetric image

Publications

Carbazole Alkaloids from <i>Clausena anisum-olens</i>: Isolation, Characterization, and Anti-HIV Evaluation.

Yang Jing-Hua JH   Wang Xin-Yi XY   Zhou Yi-Ping YP   Lu Rong R   Chen Chin-Ho CH   Zhang Meng-Han MH   Cheng Yung-Yi YY   Morris-Natschke Susan L SL   Lee Kuo-Hsiung KH   Wang Yun-Song YS  

Molecules (Basel, Switzerland) 20191226 1


Two new carbazole alkaloids (<b>1</b>,<b>2</b>) and six known carbazole alkaloids (<b>3</b>-<b>8</b>) were isolated from <i>Clausena anisum-olens</i>. Their structures were elucidated based on extensive spectroscopic analysis. All isolated compounds (<b>1</b>-<b>8</b>) were evaluated for their anti-HIV effects on virus replication in MT-4 lymphocytes infected by HIV-1<sub>NL4-3</sub> Nanoluc-sec virus, and new carbazole alkaloid <b>1</b> exhibited anti-HIV activity with an EC<sub>50</sub> value  ...[more]

Similar Datasets

| S-EPMC6767265 | biostudies-literature
| PRJNA758156 | ENA
| S-EPMC8725899 | biostudies-literature
| S-EPMC6253833 | biostudies-literature
| S-EPMC6378073 | biostudies-other
| S-EPMC8469674 | biostudies-literature
| S-EPMC8951546 | biostudies-literature
| S-EPMC7932029 | biostudies-literature
| S-EPMC5822041 | biostudies-literature
| S-EPMC3715147 | biostudies-literature