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Carbazole Alkaloids from Clausena anisum-olens: Isolation, Characterization, and Anti-HIV Evaluation.

ABSTRACT: Two new carbazole alkaloids (1,2) and six known carbazole alkaloids (3-8) were isolated from Clausena anisum-olens. Their structures were elucidated based on extensive spectroscopic analysis. All isolated compounds (1-8) were evaluated for their anti-HIV effects on virus replication in MT-4 lymphocytes infected by HIV-1NL4-3 Nanoluc-sec virus, and new carbazole alkaloid 1 exhibited anti-HIV activity with an EC50 value of 2.4 ?g/mL and SI of 7.1.

SUBMITTER: Yang JH

PROVIDER: S-EPMC6983056 | biostudies-literature | 2019 Dec

REPOSITORIES: biostudies-literature

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Carbazole Alkaloids from Clausena anisum-olens: Isolation, Characterization, and Anti-HIV Evaluation.

Yang Jing-Hua JH Wang Xin-Yi XY Zhou Yi-Ping YP Lu Rong R Chen Chin-Ho CH Zhang Meng-Han MH Cheng Yung-Yi YY Morris-Natschke Susan L SL Lee Kuo-Hsiung KH Wang Yun-Song YS

Molecules (Basel, Switzerland) 20191226 1

Two new carbazole alkaloids (1,2) and six known carbazole alkaloids (3-8) were isolated from Clausena anisum-olens. Their structures were elucidated based on extensive spectroscopic analysis. All isolated compounds (1-8) were evaluated for their anti-HIV effects on virus replication in MT-4 lymphocytes infected by HIV-1NL4-3 Nanoluc-sec virus, and new carbazole alkaloid 1 exhibited anti-HIV activity with an EC50 value ...[more]

PMID: 31888067

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