Ontology highlight
ABSTRACT:
SUBMITTER: de Munnik M
PROVIDER: S-EPMC6984337 | biostudies-literature | 2019 Aug
REPOSITORIES: biostudies-literature
de Munnik Mariska M Lohans Christopher T CT Lang Pauline A PA Langley Gareth W GW Malla Tika R TR Tumber Anthony A Schofield Christopher J CJ Brem Jürgen J
Chemical communications (Cambridge, England) 20190801 69
The l,d-transpeptidases (Ldts) are promising antibiotic targets for treating tuberculosis. We report screening of cysteine-reactive inhibitors against LdtMt2 from Mycobacterium tuberculosis. Structural studies on LdtMt2 with potent inhibitor ebselen reveal opening of the benzisoselenazolone ring by a nucleophilic cysteine, forming a complex involving extensive hydrophobic interactions with a substrate-binding loop. ...[more]