Ontology highlight
ABSTRACT:
SUBMITTER: Zhao H
PROVIDER: S-EPMC6987283 | biostudies-literature | 2020 Jan
REPOSITORIES: biostudies-literature
Zhao Hongyu H Wang Yunfei Y Yang Chao C Zhou Junhu J Wang Lin L Yi Kaikai K Li Yansheng Y Wang Qixue Q Shi Jin J Kang Chunsheng C Zeng Liang L
Clinical and translational medicine 20200128 1
<h4>Background</h4>The EGFR-vIII mutation is the most common malignant event in GBM. Epigenetic reprogramming in EGFR-activated GBM has recently been suggested to downregulate the expression of tumour suppressor genes. Histone acetylation is important for chromatin structure and function. However, the role and biological function of H2AZK4/7AC in tumours have not yet been clarified.<h4>Results</h4>In our study, we found that EGFR-vIII negatively regulated H2AZK4/7AC expression though the PI3K/AK ...[more]