Ontology highlight
ABSTRACT:
SUBMITTER: Zhou W
PROVIDER: S-EPMC6989475 | biostudies-literature | 2019
REPOSITORIES: biostudies-literature
Zhou Wenyang W Yang Fan F Xu Zhaochun Z Luo Meng M Wang Pingping P Guo Yu Y Nie Huan H Yao Lifen L Jiang Qinghua Q
Frontiers in genetics 20200123
Clear-cell renal cell carcinoma (ccRCC) is the most common and lethal subtype of kidney cancer. <i>VHL</i> and <i>PBRM1</i> are the top two significantly mutated genes in ccRCC specimens, while the genetic mechanism of the <i>VHL/PBRM1</i>-negative ccRCC remains to be elucidated. Here we carried out a comprehensive analysis of single-cell genomic copy number variations (CNVs) in <i>VHL/PBRM1</i>-negative ccRCC. Genomic CNVs were identified at the single-cell level, and the tumor cells showed wid ...[more]