Ontology highlight
ABSTRACT:
SUBMITTER: Ballabio C
PROVIDER: S-EPMC6989674 | biostudies-literature | 2020 Jan
REPOSITORIES: biostudies-literature
Ballabio Claudio C Anderle Marica M Gianesello Matteo M Lago Chiara C Miele Evelina E Cardano Marina M Aiello Giuseppe G Piazza Silvano S Caron Davide D Gianno Francesca F Ciolfi Andrea A Pedace Lucia L Mastronuzzi Angela A Tartaglia Marco M Locatelli Franco F Ferretti Elisabetta E Giangaspero Felice F Tiberi Luca L
Nature communications 20200129 1
Medulloblastoma (MB) is the most common malignant brain tumor in children and among the subtypes, Group 3 MB has the worst outcome. Here, we perform an in vivo, patient-specific screen leading to the identification of Otx2 and c-MYC as strong Group 3 MB inducers. We validated our findings in human cerebellar organoids where Otx2/c-MYC give rise to MB-like organoids harboring a DNA methylation signature that clusters with human Group 3 tumors. Furthermore, we show that SMARCA4 is able to reduce O ...[more]