[Spatial/temporal analysis of the incidence of certain cancers by sites in Quebec: 1984-1986 and 1989-1991].
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ABSTRACT:
SUBMITTER: Thouez JP
PROVIDER: S-EPMC6990280 | biostudies-literature | 1997 Jan-Feb
REPOSITORIES: biostudies-literature
Publications
[Spatial/temporal analysis of the incidence of certain cancers by sites in Quebec: 1984-1986 and 1989-1991].
Thouez J P JP Emard J F JF Beaupré M M Latreille J J Ghadirian P P
Canadian journal of public health = Revue canadienne de sante publique 19970101 1
Basing our views on recent works of an Ontarian research group, we analyze the profiles of incidence of the main types of cancers observed in the province of Québec for the periods 1984-1986 and 1989-1991. Using the Québec Tumors Registry, we have calculated standardized incidence rates according to sex for each of the 32 departments of community health in the province. A geographical analysis of cancers was conducted via two methods of spatial autocorrelation (SA). Many cancer sites (i.e., brea ...[more]
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Project description:Determining mechanisms that naturally protect species from developing cancer is critical in order to prevent and treat cancer. Here, we describe a novel cancer-suppressing mechanism, via the secretion of bioactive factors by mammary cells, that is present in domesticated mammals with a low mammary cancer incidence. Specifically, these bioactive factors induced triple-negative breast cancer cell (TNBC) death in vitro and reduced tumorigenicity in a xenograft TNBC mouse model in vivo. RNA deep sequencing showed significant downregulation of genes associated with breast cancer progression in secretome-cultured TNBC cells. Further in-depth multi-omics analysis identified sphingomyelins as key secreted factors, and their role was confirmed via inhibition of the sphingomyelin signaling pathway. We speculate that secreted sphingomyelins in the mammary gland of mammals with a naturally low incidence of mammary cancer mediate the elimination of cancer cells. This study contributes to the growing list of protective mechanisms identified in cancer-proof species.
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