Ontology highlight
ABSTRACT:
SUBMITTER: Yagi-Utsumi M
PROVIDER: S-EPMC6992696 | biostudies-literature | 2020 Jan
REPOSITORIES: biostudies-literature
Yagi-Utsumi Maho M Sikdar Arunima A Song Chihong C Park Jimin J Inoue Rintaro R Watanabe Hiroki H Burton-Smith Raymond N RN Kozai Toshiya T Suzuki Tatsuya T Kodama Atsuji A Ishii Kentaro K Yagi Hirokazu H Satoh Tadashi T Uchiyama Susumu S Uchihashi Takayuki T Joo Keehyoung K Lee Jooyoung J Sugiyama Masaaki M Murata Kazuyoshi K Kato Koichi K
Scientific reports 20200130 1
Euryarchaeal genomes encode proteasome-assembling chaperone homologs, PbaA and PbaB, although archaeal proteasome formation is a chaperone-independent process. Homotetrameric PbaB functions as a proteasome activator, while PbaA forms a homopentamer that does not interact with the proteasome. Notably, PbaA forms a complex with PF0014, an archaeal protein without functional annotation. In this study, based on our previous research on PbaA crystal structure, we performed an integrative analysis of ...[more]