The endocrine disruptor DEHP and the ECS: analysis of a possible crosstalk.
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ABSTRACT:
SUBMITTER: Ernst J
PROVIDER: S-EPMC6993259 | biostudies-literature | 2020 Feb
REPOSITORIES: biostudies-literature
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The endocrine disruptor DEHP and the ECS: analysis of a possible crosstalk.
Ernst Jana J Grabiec Urszula U Falk Kathrin K Dehghani Faramarz F Schaedlich Kristina K
Endocrine connections 20200201 2
Studies of the last decade associated the environmental contamination by di-(2-ethylhexyl)-phthalate (DEHP) with obesity and endocrine malfunction. DEHP was found to interact with several receptors - among them are receptors of the endocannabinoid system (ECS) with high expression levels in adipose tissue. Furthermore, the correlation for BMI and body fat to the serum endocannabinoid level raises the question if the obesogenic and endocrine-disrupting DEHP effects are mediated via the ECS. We th ...[more]
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