Ontology highlight
ABSTRACT:
SUBMITTER: Alanazi B
PROVIDER: S-EPMC6995695 | biostudies-literature | 2020 Feb
REPOSITORIES: biostudies-literature
Alanazi Bader B Munje Chinmay R CR Rastogi Namrata N Williamson Andrew J K AJK Taylor Samuel S Hole Paul S PS Hodges Marie M Doyle Michelle M Baker Sarah S Gilkes Amanda F AF Knapper Steven S Pierce Andrew A Whetton Anthony D AD Darley Richard L RL Tonks Alex A
Leukemia 20191014 2
Inappropriate localization of proteins can interfere with normal cellular function and drive tumor development. To understand how this contributes to the development of acute myeloid leukemia (AML), we compared the nuclear proteome and transcriptome of AML blasts with normal human CD34<sup>+</sup> cells. Analysis of the proteome identified networks and processes that significantly affected transcription regulation including misexpression of 11 transcription factors with seven proteins not previo ...[more]