Ontology highlight
ABSTRACT:
SUBMITTER: Personnaz J
PROVIDER: S-EPMC6996376 | biostudies-literature | 2019 Apr
REPOSITORIES: biostudies-literature
Personnaz Jean J Piccolo Enzo E Branchereau Maxime M Filliol Aveline A Paccoud Romain R Moreau Elsa E Calise Denis D Riant Elodie E Gourdy Pierre P Heymes Christophe C Schwabe Robert F RF Dray Cédric C Valet Philippe P Pradère Jean-Philippe JP
FASEB bioAdvances 20190212 4
Alarmins and damage-associated molecular patterns (DAMPs) are powerful inflammatory mediators, capable of initiating and maintaining sterile inflammation during acute or chronic tissue injury. Recent evidence suggests that alarmins/DAMPs may also trigger tissue regeneration and repair, suggesting a potential contribution to tissue fibrogenesis. High mobility group B1 (HMGB1), a bona fide alarmin/DAMP, may be released passively by necrotic cells or actively secreted by innate immune cells. Macrop ...[more]