Ontology highlight
ABSTRACT:
SUBMITTER: Belman JP
PROVIDER: S-EPMC6996523 | biostudies-literature | 2020 Feb
REPOSITORIES: biostudies-literature
Belman Jonathan P JP Meng Wenzhao W Wang Hong Yi HY Li Jie J Strauser Honore T HT Rosenfeld Aaron M AM Zhang Qian Q Prak Eline T Luning ETL Wasik Mariusz M
Cold Spring Harbor molecular case studies 20200203 1
Transformation of follicular lymphoma (FL) into B-lymphoblastic leukemia/lymphoma (B-ALL/LBL) is rare and results in greatly increased aggressiveness of clinical course. Here we present extensive molecular analysis of this unusual transformation, including immunoglobulin (Ig) gene rearrangement studies, cytogenetic analysis, and whole-exome sequencing (WES) of the patient's FL, B-ALL/LBL, and normal cells. Although FL showed marked somatic hypermutation (SHM) of the Ig genes, SHM appeared to be ...[more]