Ontology highlight
ABSTRACT:
SUBMITTER: Zhang M
PROVIDER: S-EPMC6996575 | biostudies-literature | 2020 Feb
REPOSITORIES: biostudies-literature
Zhang Miao M Liang Cai C Chen Qinfu Q Yan Haiyan H Xu Junfen J Zhao Hongxia H Yuan Xueying X Liu Jingbo J Lin Shixian S Lu Weiguo W Wang Fangwei F
The EMBO journal 20191126 3
Chromosome segregation in mitosis requires the removal of catenation between sister chromatids. Timely decatenation of sister DNAs at mitotic centromeres by topoisomerase IIα (TOP2A) is crucial to maintain genomic stability. The chromatin factors that recruit TOP2A to centromeres during mitosis remain unknown. Here, we show that histone H2A Thr-120 phosphorylation (H2ApT120), a modification generated by the mitotic kinase Bub1, is necessary and sufficient for the centromeric localization of TOP2 ...[more]