Myeloid-Derived Suppressor Cells and ??T17 Cells Contribute to the Development of Gastric MALT Lymphoma in H. felis-Infected Mice.

ABSTRACT: Helicobacter-induced chronic inflammation and immune disorders are closely associated with the development of gastric mucosa-associated lymphoid tissue (MALT) lymphoma. Myeloid-derived suppressor cells (MDSCs) exhibit strong immunosuppressive properties and promote the growth of various solid tumors. However, the role of MDSCs in the development of MALT lymphoma has not been elucidated so far. We detected significant infiltration and enrichment of MDSCs in patients with MALT lymphoma, as well in Helicobacter felis-infected mouse model of gastric MALT lymphoma. In addition, the expression of arginase-1 and inducible nitric oxide synthase was significantly elevated both in gastric MALT lymphoma tissues and H. felis-infected stomach. Persistent H. felis infection closely reproduced the development of gastric MALT lymphoma and was accompanied by increased numbers of ??T17 cells. Accumulation of ??T17 cells was also validated in the human gastric MALT lymphoma tissues. Furthermore, the elevated cytokines interleukin-23 and interleukin-1?, as well as chemokines CCL20/CCR6, may be involved in the accumulation of ??T17 cells and the subsequent immunosuppression. These findings highlight the role of MDSCs and ??T17 cells in immune dysregulation during gastric MALT lymphoma development and their potential as therapeutic targets.

SUBMITTER: Zhao Y 

PROVIDER: S-EPMC6998799 | biostudies-literature | 2019

REPOSITORIES: biostudies-literature