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Creep and permeability evolution behavior of red sandstone containing a single fissure under a confining pressure of 30?MPa.

ABSTRACT: The long-term deformation and permeability evolution with time are key issues for geo-engineering applications such as radioactive waste disposal. Rock permeability concurrent with deformation is significantly influenced by cracking. This study investigated the creep-permeability evolution behavior of red sandstone specimens containing a single fissure under a confining pressure of 30?MPa. First, the effects of stress ratio (SR) and fissure dip angle on the creep behavior of rock were investigated. The more loading/unloading cyclic numbers, the larger the irrecoverable axial deformation. The instant elastic strains and visco-elastic strains linearly increased with SR for both the intact and fissured specimens, whereas the instant plastic strains showed different results. The visco-plastic strains nonlinearly increased. For fissured and intact specimens, the creep strains and the steady-state creep rates nonlinearly increased as SR increased. The instantaneous strains, instant elastic strains, and visco-elastic strains slightly varied when the fissure dip angle was less than 45° but notably decreased with increasing fissure dip angle beyond 45°. However, the fissure dip angle had no obvious effects on the plastic and creep strains. Damage (D) was defined using the ratio of non-elastic strains to the total strain. D increased approximately linearly with SR, but the fissure dip angle had no obvious influences. Subsequently, the long-term strength (LTS) of the red sandstone was determined using two different methods. The LTS first decreased when the fissure dip angle increased from 0 to 45° but increased with increasing dip angle. The triaxial and creep failure modes were mainly shear along anti-wing cracks for the fissured specimens but shear failure occurred for the intact specimen. Moreover, the permeability of the fissured red sandstone was governed by SR and deformation or time. During the multi-step loading/unloading creep process, the permeability first decreased and then had a sudden rise when tertiary creep occurred.

SUBMITTER: Yang SQ

PROVIDER: S-EPMC7002402 | biostudies-literature | 2020 Feb

REPOSITORIES: biostudies-literature

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Creep and permeability evolution behavior of red sandstone containing a single fissure under a confining pressure of 30 MPa.

Yang Sheng-Qi SQ Hu Bo B

Scientific reports 20200205 1

The long-term deformation and permeability evolution with time are key issues for geo-engineering applications such as radioactive waste disposal. Rock permeability concurrent with deformation is significantly influenced by cracking. This study investigated the creep-permeability evolution behavior of red sandstone specimens containing a single fissure under a confining pressure of 30 MPa. First, the effects of stress ratio (SR) and fissure dip angle on the creep behavior of rock were investigat ...[more]

PMID: 32024874

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Project description:UnlabelledMycophenolic acid (MPA) is prescribed to maintain allografts in organ-transplanted patients. However, gastrointestinal (GI) complications, particularly diarrhea, are frequently observed as a side effect following MPA therapy. We recently reported that MPA altered the tight junction (TJ)-mediated barrier function in a Caco-2 cell monolayer model system. This study investigates whether MPA induces epigenetic changes which lead to GI complications, especially diarrhea.MethodsWe employed a Chromatin Immunoprecipitation-O-Proteomics (ChIP-O-Proteomics) approach to identify proteins associated with active (H3K4me3) as well as repressive (H3K27me3) chromatin histone modifications in MPA-treated cells, and further characterized the role of midkine, a H3K4me3-associated protein, in the context of epithelial monolayer permeability.ResultsWe identified a total of 333 and 306 proteins associated with active and repressive histone modification marks, respectively. Among them, 241 proteins were common both in active and repressive chromatin, 92 proteins were associated exclusively with the active histone modification mark, while 65 proteins remained specific to repressive chromatin. Our results show that 45 proteins which bind to the active and seven proteins which bind to the repressive chromatin region exhibited significantly altered abundance in MPA-treated cells as compared to DMSO control cells. A number of novel proteins whose function is not known in bowel barrier regulation were among the identified proteins, including midkine. Our functional integrity assays on the Caco-2 cell monolayer showed that the inhibition of midkine expression prior to MPA treatment could completely block the MPA-mediated increase in barrier permeability.ConclusionsThe ChIP-O-Proteomics approach delivered a number of novel proteins with potential implications in MPA toxicity. Consequently, it can be proposed that midkine inhibition could be a potent therapeutic approach to prevent the MPA-mediated increase in TJ permeability and leak flux diarrhea in organ transplant patients.

Dataset Information

Creep and permeability evolution behavior of red sandstone containing a single fissure under a confining pressure of 30?MPa.

Publications

Creep and permeability evolution behavior of red sandstone containing a single fissure under a confining pressure of 30 MPa.

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