Ontology highlight
ABSTRACT:
SUBMITTER: Imaizumi Y
PROVIDER: S-EPMC7002495 | biostudies-literature | 2020 Feb
REPOSITORIES: biostudies-literature
Imaizumi Yui Y Furutachi Shohei S Watanabe Tomoyuki T Miya Hiroaki H Kawaguchi Daichi D Gotoh Yukiko Y
Scientific reports 20200205 1
Imprinted genes are expressed from only one allele in a parent of origin-specific manner. The cyclin-dependent kinase inhibitor p57<sup>kip2</sup> is encoded by an imprinted gene Cdkn1c, with the paternal allele being silenced. The possible expression and function of the paternal allele of Cdkn1c have remained little studied, however. We now show that the paternal allele of the Cdkn1c gene is expressed at a low level in the developing mouse neocortex. Surprisingly, the central nervous system-spe ...[more]