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Rapid, two-pot procedure for the synthesis of dihydropyridinones; total synthesis of aza-goniothalamin.

ABSTRACT: A fast, protecting-group-free synthesis of dihydropyridinones has been developed. Starting from commercially available aldehydes, a novel one-pot amidoallylation gave access to diene compounds in good yields. Ring-closing metathesis conditions were then employed to produce the target dihydropyridinones efficiently and in high yields.

SUBMITTER: Cogswell TJ

PROVIDER: S-EPMC7006497 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature

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Rapid, two-pot procedure for the synthesis of dihydropyridinones; total synthesis of aza-goniothalamin.

Cogswell Thomas J TJ Donald Craig S CS Marquez Rodolfo R

Beilstein journal of organic chemistry 20200128

A fast, protecting-group-free synthesis of dihydropyridinones has been developed. Starting from commercially available aldehydes, a novel one-pot amidoallylation gave access to diene compounds in good yields. Ring-closing metathesis conditions were then employed to produce the target dihydropyridinones efficiently and in high yields. ...[more]

PMID: 32082432

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