Dataset Information

Pulmonary vascular density: comparison of findings on computed tomography imaging with histology.

ABSTRACT:

Background

Exposure to cigarette smoke has been shown to lead to vascular remodelling. Computed tomography (CT) imaging measures of vascular pruning have been associated with pulmonary vascular disease, an important morbidity associated with smoking. In this study we compare CT-based measures of distal vessel loss to histological vascular and parenchymal changes.

Methods

A retrospective review of 80 patients who had undergone lung resection identified patients with imaging appropriate for three-dimensional (3D) vascular reconstruction (n=18) and a second group for two-dimensional (2D) analysis (n=19). Measurements of the volume of the small vessels (3D) and the cross-sectional area of the small vessels (<5?mm² cross-section) were computed. Histological measures of cross-sectional area of the vasculature and loss of alveoli septa were obtained for all subjects.

Results

The 2D cross-sectional area of the vasculature on CT imaging was associated with the histological vascular cross-sectional area (r=0.69; p=0.001). The arterial small vessel volume assessed by CT correlated with the histological vascular cross-sectional area (r=0.50; p=0.04), a relationship that persisted even when adjusted for CT-derived measures of emphysema in a regression model.

Conclusions

Loss of small vessel volume in CT imaging of smokers is associated with histological loss of vascular cross-sectional area. Imaging-based quantification of pulmonary vasculature provides a noninvasive method to study the multiscale effects of smoking on the pulmonary circulation.

SUBMITTER: Rahaghi FN

PROVIDER: S-EPMC7007984 | biostudies-literature | 2019 Aug

REPOSITORIES: biostudies-literature

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Publications

Pulmonary vascular density: comparison of findings on computed tomography imaging with histology.

Rahaghi Farbod N FN Argemí Gemma G Nardelli Pietro P Domínguez-Fandos David D Arguis Pedro P Peinado Víctor I VI Ross James C JC Ash Samuel Y SY de La Bruere Isaac I Come Carolyn E CE Diaz Alejandro A AA Sánchez Marcelo M Washko George R GR Barberà Joan Albert JA San José Estépar Raúl R

The European respiratory journal 20190815 2

<h4>Background</h4>Exposure to cigarette smoke has been shown to lead to vascular remodelling. Computed tomography (CT) imaging measures of vascular pruning have been associated with pulmonary vascular disease, an important morbidity associated with smoking. In this study we compare CT-based measures of distal vessel loss to histological vascular and parenchymal changes.<h4>Methods</h4>A retrospective review of 80 patients who had undergone lung resection identified patients with imaging appropr ...[more]

PMID: 31196942

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Dataset Information

Pulmonary vascular density: comparison of findings on computed tomography imaging with histology.

Background

Methods

Results

Conclusions

Publications

Pulmonary vascular density: comparison of findings on computed tomography imaging with histology.

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