Ontology highlight
ABSTRACT:
SUBMITTER: Piao W
PROVIDER: S-EPMC7009789 | biostudies-literature | 2020 Jan
REPOSITORIES: biostudies-literature
Cell reports 20200101 4
Regulatory T cells (Tregs) express high levels of cell surface lymphotoxin alpha beta (LTα1β2) to activate the LT beta receptor (LTβR) on the lymphatic endothelial cells (LECs), modulating LEC adhesion molecules, intercellular junctions, and chemokines. We demonstrate a role for Tregs through this pathway to condition the permissiveness of lymphatic endothelia for transendothelial migration (TEM), thus gating leukocyte traffic. Human Tregs share the same property with murine Tregs. Activation of ...[more]