Ontology highlight
ABSTRACT:
SUBMITTER: Kaelber JT
PROVIDER: S-EPMC7010358 | biostudies-literature | 2020 Feb
REPOSITORIES: biostudies-literature
Acta crystallographica. Section F, Structural biology communications 20200203 Pt 2
Adeno-associated viruses (AAVs) are used as in vivo gene-delivery vectors in gene-therapy products and have been heavily investigated for numerous indications. Over 100 naturally occurring AAV serotypes and variants have been isolated from primate samples. Many reports have described unique properties of these variants (for instance, differences in potency, target cell or evasion of the immune response), despite high amino-acid sequence conservation. AAVhu.37 is of interest for clinical applicat ...[more]