Ontology highlight
ABSTRACT:
SUBMITTER: Osenkowski P
PROVIDER: S-EPMC2830092 | biostudies-literature | 2009 Jan
REPOSITORIES: biostudies-literature
Osenkowski Pamela P Li Hua H Ye Wenjuan W Li Dongyang D Aeschbach Lorene L Fraering Patrick C PC Wolfe Michael S MS Selkoe Dennis J DJ Li Huilin H
Journal of molecular biology 20081105 2
Gamma-secretase, an integral membrane protein complex, catalyzes the intramembrane cleavage of the beta-amyloid precursor protein (APP) during the neuronal production of the amyloid beta-peptide. As such, the protease has emerged as a key target for developing agents to treat and prevent Alzheimer's disease. Existing biochemical studies conflict on the oligomeric assembly state of the protease complex, and its detailed structure is not known. Here, we report that purified active human gamma-secr ...[more]