Ontology highlight
ABSTRACT:
SUBMITTER: Zhang C
PROVIDER: S-EPMC7011943 | biostudies-literature | 2018 Dec
REPOSITORIES: biostudies-literature
Journal of enzyme inhibition and medicinal chemistry 20181201 1
Phosphodiesterase-9 (PDE9) is a promising target for treatment of Alzheimer's disease (AD). To discover multifunctional anti-AD agents with capability of PDE9 inhibition and antioxidant activity, a series of novel pyrazolopyrimidinone derivatives, coupling with the pharmacophore of antioxidants such as ferulic and lipolic acids have been designed with the assistance of molecular docking and dynamics simulations. Twelve out of 14 synthesised compounds inhibited PDE9A with IC<sub>50</sub> below 20 ...[more]