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Replication study of susceptibility variants associated with allergic rhinitis and allergy in Han Chinese.

ABSTRACT: Background:Allergic rhinitis (AR) is believed to be a complex genetic disease. The last decade has been marked by the publication of more than 20 genome-wide association studies (GWASs) of AR and associated allergic phenotypes and allergic diseases, which have shown allergic diseases and traits to share a large number of genetic susceptibility loci. The aim of present study was therefore to investigate the highly replicated allergy related genes and variants as candidates for AR in Han Chinese subjects. Methods:A total of 762 AR patients and 760 control subjects were recruited, and a total of 58 susceptible variants previously reported to be associated with allergic traits were choose for replication. Results:Logistic regression analyses revealed that in the co-dominant-effect model as assessed by the AIC, compared with wild-type carriers, significant AR risk were associated with rs9865818 in LPP (P?=?0.029, OR?=?1.469 for GG vs. AA); rs6554809 in DNAH5 (P?=?0.000, OR?=?1.597 for TC vs. CC); rs1438673 in WDR36-CAMK4 loci (P?=?0.037, OR?=?1.396 for CC vs.TT), rs7775228 in HLA region (P?=?0.000, OR?=?1.589 for TC vs.TT), rs7203459 in CLEC16A (P?=?0.025, OR?=?0.731 for TC vs. TT). Conclusion:We replicated Han Chinese AR-specific susceptibility loci in LPP, DNAH5, HLA, CLEC16A and WDR36-CAMK4. Further understanding the molecular mechanisms underlying these associations may provide new insights into the etiology of allergic disease.

SUBMITTER: Gao Y

PROVIDER: S-EPMC7014941 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature

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Replication study of susceptibility variants associated with allergic rhinitis and allergy in Han Chinese.

Gao Yunbo Y Li Jingyun J Zhang Yuan Y Zhang Luo L

Allergy, asthma, and clinical immunology : official journal of the Canadian Society of Allergy and Clinical Immunology 20200211

<h4>Background</h4>Allergic rhinitis (AR) is believed to be a complex genetic disease. The last decade has been marked by the publication of more than 20 genome-wide association studies (GWASs) of AR and associated allergic phenotypes and allergic diseases, which have shown allergic diseases and traits to share a large number of genetic susceptibility loci. The aim of present study was therefore to investigate the highly replicated allergy related genes and variants as candidates for AR in Han C ...[more]

PMID: 32082391

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Project description:PurposeHouse dust mite (HDM) is the predominant cause of allergic rhinitis (AR) in Hong Kong but remains under-diagnosed and -treated. The association between patient-reported outcome measures (PROMs) and nasoendoscopy findings for AR have also not been investigated. This study investigated the demographics, sensitisation patterns, quality of life, use of sublingual immunotherapy and the association of PROMs and nasoendoscopy findings in AR patients through the first allergist-otorhinolaryngologists AR joint (ARJ) clinic in Hong Kong.MethodsThis single-centred, retrospective observational study was conducted between January 2021 and December 2021. Clinical data from AR patients attending the ARJ clinic were analysed to identify the prevalence of HDM allergens, change in PROMs and the association of PROMs with nasoendoscopy scores.ResultsThe three most common sensitising HDM allergens were Dermatophagoides pterynosinus (94.4%), Dermatophagoides farinae (88.9%) and Euroglyphus maynei (88.9%). At the 13- to 32-week follow-up (median 28 weeks), patients who attended the ARJ clinic had significant improvement in Total Nasal Symptom Score (TNSS; p = 0.038). The visual analogue scale (VAS) was associated with nasoendoscopy score (p = 0.018). Patients using SLIT (sublingual immunotherapy) showed overall improvements in PROMs.ConclusionThe ARJ clinic significantly improved AR symptoms. SLIT was effective and safe for patients who failed conventional treatments. VAS positively correlated with nasoendoscopy findings. Testing for Dermatophagoides pterynosinus as a single agent during skin testing was sufficient for the diagnosis of HDM AR and should be prioritized when resources are restricted. Further studies should be done to investigate the treatment outcome of AR patients and the effectiveness of SLIT in the Chinese population.Supplementary informationThe online version of this article (10.1007/s40629-022-00218-5) contains supplementary material, which is available to authorized users.

Dataset Information

Replication study of susceptibility variants associated with allergic rhinitis and allergy in Han Chinese.

Publications

Replication study of susceptibility variants associated with allergic rhinitis and allergy in Han Chinese.

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