Ontology highlight
ABSTRACT:
SUBMITTER: Durham ND
PROVIDER: S-EPMC7019799 | biostudies-literature | 2020 Jan
REPOSITORIES: biostudies-literature
Durham Natasha D ND Howard Angela R AR Govindan Ramesh R Senjobe Fernando F Fels J Maximilian JM Diehl William E WE Luban Jeremy J Chandran Kartik K Munro James B JB
Viruses 20200115 1
The Ebola virus (EBOV) envelope glycoprotein (GP) mediates the fusion of the virion membrane with the membrane of susceptible target cells during infection. While proteolytic cleavage of GP by endosomal cathepsins and binding of the cellular receptor Niemann-Pick C1 protein (NPC1) are essential steps for virus entry, the detailed mechanisms by which these events promote membrane fusion remain unknown. Here, we applied single-molecule Förster resonance energy transfer (smFRET) imaging to investig ...[more]