Ontology highlight
ABSTRACT:
SUBMITTER: Jaskierny AJ
PROVIDER: S-EPMC3075865 | biostudies-literature | 2011 Apr
REPOSITORIES: biostudies-literature
Jaskierny Adam J AJ Panahi Afra A Feig Michael M
Proteins 20110118 4
Fusion peptides mediate viral and host-cell membrane fusion during viral entry. The monomeric form of the internal fusion peptide from Ebola virus was studied in membrane bilayer and water environments with computer simulations using replica exchange sampling and an implicit solvent description of the environment. Wild-type Ebola fusion peptide (EFP), the W8A mutant form, and an extended construct with flanking residues were examined. It was found that the monomeric form of wild-type EFP adopts ...[more]