Ontology highlight
ABSTRACT:
SUBMITTER: Yu RJ
PROVIDER: S-EPMC7020925 | biostudies-literature | 2019 Dec
REPOSITORIES: biostudies-literature
Yu Ru-Jia RJ Lu Si-Min SM Xu Su-Wen SW Li Yuan-Jie YJ Xu Qun Q Ying Yi-Lun YL Long Yi-Tao YT
Chemical science 20191008 46
We have developed a glass nanopore based single molecule tool to investigate the dynamic oligomerization and aggregation process of Aβ1-42 peptides. The intrinsic differences in the molecular size and surface charge of amyloid aggregated states could be distinguished through single molecule induced characteristic current fluctuation. More importantly, our results reveal that the neurotoxic Aβ1-42 oligomer tends to adsorb onto the solid surface of nanopores, which may explain its instability and ...[more]