Ontology highlight
ABSTRACT:
SUBMITTER: Drews JD
PROVIDER: S-EPMC7478265 | biostudies-literature | 2020 Apr
REPOSITORIES: biostudies-literature
Drews Joseph D JD Pepper Victoria K VK Best Cameron A CA Szafron Jason M JM Cheatham John P JP Yates Andrew R AR Hor Kan N KN Zbinden Jacob C JC Chang Yu-Chun YC Mirhaidari Gabriel J M GJM Ramachandra Abhay B AB Miyamoto Shinka S Blum Kevin M KM Onwuka Ekene A EA Zakko Jason J Kelly John J Cheatham Sharon L SL King Nakesha N Reinhardt James W JW Sugiura Tadahisa T Miyachi Hideki H Matsuzaki Yuichi Y Breuer Julie J Heuer Eric D ED West T Aaron TA Shoji Toshihiro T Berman Darren D Boe Brian A BA Asnes Jeremy J Galantowicz Mark M Matsumura Goki G Hibino Narutoshi N Marsden Alison L AL Pober Jordan S JS Humphrey Jay D JD Shinoka Toshiharu T Breuer Christopher K CK
Science translational medicine 20200401 537
We developed a tissue-engineered vascular graft (TEVG) for use in children and present results of a U.S. Food and Drug Administration (FDA)-approved clinical trial evaluating this graft in patients with single-ventricle cardiac anomalies. The TEVG was used as a Fontan conduit to connect the inferior vena cava and pulmonary artery, but a high incidence of graft narrowing manifested within the first 6 months, which was treated successfully with angioplasty. To elucidate mechanisms underlying this ...[more]