Dataset Information

The Detection and Reactivity of Silanols and Silanes Using Hyperpolarized ²⁹ Si Nuclear Magnetic Resonance.

ABSTRACT: Silanols and silanes are key precursors and intermediates for the synthesis of silicon-based materials. While their characterization and quantification by ²⁹ Si NMR spectroscopy has received significant attention, it is a technique that is limited by the low natural abundance of ²⁹ Si and its low sensitivity. Here, we describe a method using p-H₂ to hyperpolarize ²⁹ Si. The observed signal enhancements, approaching 3000-fold at 11.7?T, would take many days of measurement for comparable results under Boltzmann conditions. The resulting signals were exploited to monitor the rapid reaction of tris(tert-butoxy)silanol with triflic anhydride in a T₁ -corrected process that allows for rapid quantification. These results demonstrate a novel route to quantify dynamic processes and intermediates in the synthesis of silicon materials.

SUBMITTER: Rayner PJ

PROVIDER: S-EPMC7027454 | biostudies-literature | 2020 Feb

REPOSITORIES: biostudies-literature

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Publications

The Detection and Reactivity of Silanols and Silanes Using Hyperpolarized 29 Si Nuclear Magnetic Resonance.

Rayner Peter J PJ Richardson Peter M PM Duckett Simon B SB

Angewandte Chemie (International ed. in English) 20200109 7

Silanols and silanes are key precursors and intermediates for the synthesis of silicon-based materials. While their characterization and quantification by 29 Si NMR spectroscopy has received significant attention, it is a technique that is limited by the low natural abundance of 29 Si and its low sensitivity. Here, we describe a method using p-H2 to hyperpolarize 29 Si. The observed signal enhancements, approaching 3000-fold at 11.7 T, would take many ...[more]

PMID: 31833623

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Project description:BackgroundOptimal treatment selection for localized renal tumors is challenging because of their variable biologic behavior and limitations in the preoperative assessment of tumor aggressiveness. The authors investigated the emerging hyperpolarized (HP) 13 C magnetic resonance imaging (MRI) technique to noninvasively assess tumor lactate production, which is strongly associated with tumor aggressiveness.MethodsEleven patients with renal tumors underwent HP 13 C pyruvate MRI before surgical resection. Tumor 13 C pyruvate and 13 C lactate images were acquired dynamically. Five patients underwent 2 scans on the same day to assess the intrapatient reproducibility of HP 13 C pyruvate MRI. Tumor metabolic data were compared with histopathology findings.ResultsEight patients had tumors with a sufficient metabolite signal-to-noise ratio for analysis; an insufficient tumor signal-to-noise ratio was noted in 2 patients, likely caused by poor tumor perfusion and, in 1 patient, because of technical errors. Of the 8 patients, 3 had high-grade clear cell renal cell carcinoma (ccRCC), 3 had low-grade ccRCC, and 2 had chromophobe RCC. There was a trend toward a higher lactate-to-pyruvate ratio in high-grade ccRCCs compared with low-grade ccRCCs. Both chromophobe RCCs had relatively high lactate-to-pyruvate ratios. Good reproducibility was noted across the 5 patients who underwent 2 HP 13 C pyruvate MRI scans on the same day.ConclusionsThe current results demonstrate the feasibility of HP 13 C pyruvate MRI for investigating the metabolic phenotype of localized renal tumors. The initial data indicate good reproducibility of metabolite measurements. In addition, the metabolic data indicate a trend toward differentiating low-grade and high-grade ccRCCs, the most common subtype of renal cancer.Lay summaryRenal tumors are frequently discovered incidentally because of the increased use of medical imaging, but it is challenging to identify which aggressive tumors should be treated. A new metabolic imaging technique was applied to noninvasively predict renal tumor aggressiveness. The imaging results were compared with tumor samples taken during surgery and showed a trend toward differentiating between low-grade and high-grade clear cell renal cell carcinomas, which are the most common type of renal cancers.

Dataset Information

The Detection and Reactivity of Silanols and Silanes Using Hyperpolarized ²⁹ Si Nuclear Magnetic Resonance.

Publications

The Detection and Reactivity of Silanols and Silanes Using Hyperpolarized <sup>29</sup> Si Nuclear Magnetic Resonance.

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