Ontology highlight
ABSTRACT:
SUBMITTER: Zhao Y
PROVIDER: S-EPMC7031317 | biostudies-literature | 2020 Feb
REPOSITORIES: biostudies-literature
Zhao Yanan Y Wu Xuanyuan X Chen Xin X Li Jianan J Tian Cuiping C Chen Jiangrui J Xiao Cheng C Zhong Guisheng G He Shuijin S
iScience 20200201 2
The axon initial segment (AIS) cytoskeleton undergoes rapid and irreversible disruption prior to cell death after injury, and loss of AIS integrity can produce profound neurological effects on the nervous system. Here we described a previously unrecognized mechanism for ischemia-induced alterations in AIS integrity. We show that in hippocampal CA1 pyramidal neurons Na<sub>v</sub>1.6 mostly preserves at the AIS after disruption of the cytoskeleton in a mouse model of middle cerebral artery occlus ...[more]