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Cyanomethylation of Substituted Fluorenes and Oxindoles with Alkyl Nitriles.

ABSTRACT: The first example of metal-free cyanomethylenation from alkyl nitriles of sp³ C-H bonds to afford quaternary carbon centers is described. This oxidative protocol is operationally simple and features good functional group compatibility. This method provides a novel approach to highly functionalized fluorene and oxindole derivatives, which are commonly used in material and pharmaceutical areas. Control experiments provide evidence of a radical reaction process.

SUBMITTER: Hong G

PROVIDER: S-EPMC7036039 | biostudies-literature |

REPOSITORIES: biostudies-literature

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Oxidative 1,2-carboamination of alkenes with alkyl nitriles and amines toward γ-amino alkyl nitriles.

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Project description: Not available

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