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Aspidoptoids A-D: Four New Diterpenoids from Aspidopterys obcordata Vine.

ABSTRACT: Four new diterpenoids, named aspidoptoids A-D (1-4), together with two known analogues (5-6) were isolated from Aspidopterys obcordata vine. Aspidoptoids A-B (1-2) are the first examples of phenylethylene-bearing 20-nor-diterpenoids of which aspidoptoid B (2) possesses a rare 3,10-oxybridge. Their structures and absolute configuration were determined by extensive spectroscopic analyses (IR, HRESIMS, 1D and 2D NMR) and electronic circular dichroism (ECD) calculation. In addition, all the isolates were evaluated for their cytotoxic activities and inhibitory effects on the nitric oxide (NO) production.

SUBMITTER: Sun P

PROVIDER: S-EPMC7036900 | biostudies-literature | 2020 Jan

REPOSITORIES: biostudies-literature

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Aspidoptoids A-D: Four New Diterpenoids from Aspidopterys obcordata Vine.

Sun Peng P Cao Dong-Hua DH Xiao Yi-Dian YD Zhang Zong-Yi ZY Wang Jia-Nan JN Shi Xiao-Cui XC Xiao Chun-Fen CF Hu Hua-Bin HB Xu You-Kai YK

Molecules (Basel, Switzerland) 20200125 3

Four new diterpenoids, named aspidoptoids A-D (1-4), together with two known analogues (5-6) were isolated from Aspidopterys obcordata vine. Aspidoptoids A-B (1-2) are the first examples of phenylethylene-bearing 20-nor-diterpenoids of which aspidoptoid B (2) possesses a rare 3,10-oxybridge. Their structures and absolute configuration were determined by extensive spectroscopic analyses (IR, HRESIMS, 1D and 2D NMR) and electronic circular di ...[more]

PMID: 31991808

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