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The Roles of FoxO Transcription Factors in Regulation of Bone Cells Function.

ABSTRACT: Forkhead box class O family member proteins (FoxOs) are evolutionarily conserved transcription factors for their highly conserved DNA-binding domain. In mammalian species, all the four FoxO members, FoxO1, FoxO3, FoxO4, and FoxO6, are expressed in different organs. In bone, the first three members are extensively expressed and more studied. Bone development, remodeling, and homeostasis are all regulated by multiple cell lineages, including osteoprogenitor cells, chondrocytes, osteoblasts, osteocytes, osteoclast progenitors, osteoclasts, and the intercellular signaling among these bone cells. The disordered FoxOs function in these bone cells contribute to osteoarthritis, osteoporosis, or other bone diseases. Here, we review the current literature of FoxOs for their roles in bone cells, focusing on helping researchers to develop new therapeutic approaches and prevent or treat the related bone diseases.

SUBMITTER: Ma X

PROVIDER: S-EPMC7037875 | biostudies-literature | 2020 Jan

REPOSITORIES: biostudies-literature

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The Roles of FoxO Transcription Factors in Regulation of Bone Cells Function.

Ma Xiaoli X Su Peihong P Yin Chong C Lin Xiao X Wang Xue X Gao Yongguang Y Patil Suryaji S War Abdul Rouf AR Qadir Abdul A Tian Ye Y Qian Airong A

International journal of molecular sciences 20200121 3

Forkhead box class O family member proteins (FoxOs) are evolutionarily conserved transcription factors for their highly conserved DNA-binding domain. In mammalian species, all the four FoxO members, FoxO1, FoxO3, FoxO4, and FoxO6, are expressed in different organs. In bone, the first three members are extensively expressed and more studied. Bone development, remodeling, and homeostasis are all regulated by multiple cell lineages, including osteoprogenitor cells, chondrocytes, osteoblasts, osteoc ...[more]

PMID: 31973091

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