Ontology highlight
ABSTRACT:
SUBMITTER: Sul JH
PROVIDER: S-EPMC7039961 | biostudies-literature | 2020 Feb
REPOSITORIES: biostudies-literature
Sul Jae Hoon JH Service Susan K SK Huang Alden Y AY Ramensky Vasily V Hwang Sun-Goo SG Teshiba Terri M TM Park YoungJun Y Ori Anil P S APS Zhang Zhongyang Z Mullins Niamh N Olde Loohuis Loes M LM Fears Scott C SC Araya Carmen C Araya Xinia X Spesny Mitzi M Bejarano Julio J Ramirez Margarita M Castrillón Gabriel G Gomez-Makhinson Juliana J Lopez Maria C MC Montoya Gabriel G Montoya Claudia P CP Aldana Ileana I Escobar Javier I JI Ospina-Duque Jorge J Kremeyer Barbara B Bedoya Gabriel G Ruiz-Linares Andres A Cantor Rita M RM Molina Julio J Coppola Giovanni G Ophoff Roel A RA Macaya Gabriel G Lopez-Jaramillo Carlos C Reus Victor V Bearden Carrie E CE Sabatti Chiara C Freimer Nelson B NB
Translational psychiatry 20200224 1
Current evidence from case/control studies indicates that genetic risk for psychiatric disorders derives primarily from numerous common variants, each with a small phenotypic impact. The literature describing apparent segregation of bipolar disorder (BP) in numerous multigenerational pedigrees suggests that, in such families, large-effect inherited variants might play a greater role. To identify roles of rare and common variants on BP, we conducted genetic analyses in 26 Colombia and Costa Rica ...[more]