Ontology highlight
ABSTRACT:
SUBMITTER: Hayes JC
PROVIDER: S-EPMC7041909 | biostudies-literature | 2020 Feb
REPOSITORIES: biostudies-literature
Tetrahedron letters 20191216 7
A method has been developed for the addition of benzylboronic acid pinacol ester to activated ketones including trifluoromethyl ketones in good yields. The use of DABCO as an additive was found to enhance the rate and efficiency of this reaction. In reactions of ketones with a second carbonyl group present such as an ester or amide, good chemoselectivity for the ketone was observed. Competition experiments suggest an electrophile relative reactivity order of CF<sub>2</sub>H ketone > CF<sub>3</su ...[more]