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The joint effect of maternal smoking during pregnancy and maternal pre-pregnancy overweight on infants' term birth weight.


ABSTRACT: BACKGROUND:It is well known that maternal smoking during pregnancy and maternal pre-pregnancy overweight have opposite effects on the infants' birth weight. We report on the association of the combination between both risk factors and the infants' birth weight. METHODS:We studied 3241 infants born at term in the PIAMA birth cohort. Maternal smoking during pregnancy and pre-pregnancy height and weight were self-reported. Multivariable regression analysis was performed to assess the associations between infants of mothers who only smoked during pregnancy, who only had pre-pregnancy overweight and who had both risk factors simultaneously, on term birth weight and the risk of being SGA or LGA. RESULTS:Of 3241 infants, 421 infants (13%) were born to smoking, non-overweight mothers, 514 (15.8%) to non-smoking, overweight mothers, 129 (4%) to smoking and overweight mothers and 2177 (67%) to non-smoking, non-overweight mothers (reference group). Infants of mothers who smoked and also had pre-pregnancy overweight had similar term birth weight (-?26.6?g, 95%CI: -?113.0, 59.8), SGA risk (OR?=?1.06, 95%CI: 0.56, 2.04), and LGA risk (OR?=?1.09, 95%CI: 0.61, 1.96) as the reference group. CONCLUSIONS:Our findings suggested that the effects of maternal smoking during pregnancy and maternal pre-pregnancy overweight on infants' birth weight cancel each other out. Therefore, birth weight may not be a good indicator of an infant's health status in perinatal practice because it may mask potential health risks due to these maternal risk factors when both present together.

SUBMITTER: Chattrapiban T 

PROVIDER: S-EPMC7047372 | biostudies-literature | 2020 Feb

REPOSITORIES: biostudies-literature

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The joint effect of maternal smoking during pregnancy and maternal pre-pregnancy overweight on infants' term birth weight.

Chattrapiban Thanin T   Smit Henriette A HA   Wijga Alet H AH   Brunekreef Bert B   Vonk Judith M JM   Gehring Ulrike U   van Rossem Lenie L  

BMC pregnancy and childbirth 20200227 1


<h4>Background</h4>It is well known that maternal smoking during pregnancy and maternal pre-pregnancy overweight have opposite effects on the infants' birth weight. We report on the association of the combination between both risk factors and the infants' birth weight.<h4>Methods</h4>We studied 3241 infants born at term in the PIAMA birth cohort. Maternal smoking during pregnancy and pre-pregnancy height and weight were self-reported. Multivariable regression analysis was performed to assess the  ...[more]

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