Ontology highlight
ABSTRACT:
SUBMITTER: Verbinnen I
PROVIDER: S-EPMC7051951 | biostudies-literature | 2020 Mar
REPOSITORIES: biostudies-literature
Oncogenesis 20200302 3
Nuclear Inhibitor of PP1 (NIPP1) is a conserved regulatory subunit of protein phosphatase PP1. The selective deletion of NIPP1 in mouse liver parenchymal cells or skin epidermal cells culminates in a late-onset hyperproliferation of a subset of resident progenitor cells. Although a hyperplastic phenotype is usually tumor promoting, we show here that the absence of NIPP1 conferred a strong resistance to chemically induced hepatocellular or skin carcinoma. The ablation of NIPP1 did not affect the ...[more]