Ontology highlight
ABSTRACT:
SUBMITTER: Xie S
PROVIDER: S-EPMC7054862 | biostudies-literature | 2020
REPOSITORIES: biostudies-literature
Xie Sisi S Li Shu S Tian Jing J Li Fen F
Frontiers in pharmacology 20200226
Iguratimod (IGU) is a novel synthetic small molecule disease modified anti-rheumatic drug approved only in Japan and China up to date. IGU plays an important immunomodulatory role in the synovial tissue of rheumatoid arthritis by inhibiting the production of immunoglobulins and cytokines and regulating T lymphocyte subsets. IGU also regulates bone metabolism by stimulating bone formation while inhibiting osteoclast differentiation, migration, and bone resorption. In clinical trials, IGU was show ...[more]