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Identification of novel breast cancer susceptibility loci in meta-analyses conducted among Asian and European descendants.

ABSTRACT: Known risk variants explain only a small proportion of breast cancer heritability, particularly in Asian women. To search for additional genetic susceptibility loci for breast cancer, here we perform a meta-analysis of data from genome-wide association studies (GWAS) conducted in Asians (24,206 cases and 24,775 controls) and European descendants (122,977 cases and 105,974 controls). We identified 31 potential novel loci with the lead variant showing an association with breast cancer risk at P?-8. The associations for 10 of these loci were replicated in an independent sample of 16,787 cases and 16,680 controls of Asian women (P?

SUBMITTER: Shu X 

PROVIDER: S-EPMC7057957 | biostudies-literature | 2020 Mar

REPOSITORIES: biostudies-literature

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Identification of novel breast cancer susceptibility loci in meta-analyses conducted among Asian and European descendants.

Shu Xiang X   Long Jirong J   Cai Qiuyin Q   Kweon Sun-Seog SS   Choi Ji-Yeob JY   Kubo Michiaki M   Park Sue K SK   Bolla Manjeet K MK   Dennis Joe J   Wang Qin Q   Yang Yaohua Y   Shi Jiajun J   Guo Xingyi X   Li Bingshan B   Tao Ran R   Aronson Kristan J KJ   Chan Kelvin Y K KYK   Chan Tsun L TL   Gao Yu-Tang YT   Hartman Mikael M   Kee Ho Weang W   Ito Hidemi H   Iwasaki Motoki M   Iwata Hiroji H   John Esther M EM   Kasuga Yoshio Y   Soon Khoo Ui U   Kim Mi-Kyung MK   Kong Sun-Young SY   Kurian Allison W AW   Kwong Ava A   Lee Eun-Sook ES   Li Jingmei J   Lophatananon Artitaya A   Low Siew-Kee SK   Mariapun Shivaani S   Matsuda Koichi K   Matsuo Keitaro K   Muir Kenneth K   Noh Dong-Young DY   Park Boyoung B   Park Min-Ho MH   Shen Chen-Yang CY   Shin Min-Ho MH   Spinelli John J JJ   Takahashi Atsushi A   Tseng Chiuchen C   Tsugane Shoichiro S   Wu Anna H AH   Xiang Yong-Bing YB   Yamaji Taiki T   Zheng Ying Y   Milne Roger L RL   Dunning Alison M AM   Pharoah Paul D P PDP   García-Closas Montserrat M   Teo Soo-Hwang SH   Shu Xiao-Ou XO   Kang Daehee D   Easton Douglas F DF   Simard Jacques J   Zheng Wei W  

Nature communications 20200305 1

Known risk variants explain only a small proportion of breast cancer heritability, particularly in Asian women. To search for additional genetic susceptibility loci for breast cancer, here we perform a meta-analysis of data from genome-wide association studies (GWAS) conducted in Asians (24,206 cases and 24,775 controls) and European descendants (122,977 cases and 105,974 controls). We identified 31 potential novel loci with the lead variant showing an association with breast cancer risk at P <   ...[more]

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