Ontology highlight
ABSTRACT:
SUBMITTER: Liu B
PROVIDER: S-EPMC7059183 | biostudies-literature | 2020 Mar
REPOSITORIES: biostudies-literature
Liu Bin B Pappas Charalampos G CG Ottelé Jim J Schaeffer Gaël G Jurissek Christoph C Pieters Priscilla F PF Altay Meniz M Marić Ivana I Stuart Marc C A MCA Otto Sijbren S
Journal of the American Chemical Society 20200218 9
The conditions that led to the formation of the first organisms and the ways that life originates from a lifeless chemical soup are poorly understood. The recent hypothesis of "RNA-peptide coevolution" suggests that the current close relationship between amino acids and nucleobases may well have extended to the origin of life. We now show how the interplay between these compound classes can give rise to new self-replicating molecules using a dynamic combinatorial approach. We report two strategi ...[more]