Protective Effects of Controlled Mechanical Loading of Bone in C57BL6/J Mice Subject to Disuse.
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ABSTRACT:
SUBMITTER: DeLong A
PROVIDER: S-EPMC7059829 | biostudies-literature | 2020 Mar
REPOSITORIES: biostudies-literature
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Protective Effects of Controlled Mechanical Loading of Bone in C57BL6/J Mice Subject to Disuse.
DeLong Alex A Friedman Michael A MA Tucker Scott M SM Krause Andrew R AR Kunselman Allen A Donahue Henry J HJ Lewis Gregory S GS
JBMR plus 20191227 3
Prolonged reduction in weightbearing causes bone loss. Disuse of bone is associated with recovery from common musculoskeletal injury and trauma, bed rest resulting from various medical conditions, and spaceflight. The hindlimb-suspension rodent model is popular for simulating unloading and disuse. We hypothesized that controlled mechanical loading of the tibia would protect against bone loss occurring from concurrent disuse. Additionally, we hypothesized that areas of high mechanical peak strain ...[more]
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