Unknown

Dataset Information

0

Tunable and precise miniature lithium heater for point-of-care applications.


ABSTRACT: Point-of-care diagnostic assays often involve multistep reactions, requiring a wide range of precise temperatures. Although precise heating is critical to performing these assays, it is challenging to provide it in an electricity-free format away from established infrastructure. Chemical heaters are electricity-free and use exothermic reactions. However, they are unsuitable for point-of-care multistep reactions because they sacrifice portability, have a narrow range of achievable temperatures, and long ramp-up times. Here we developed a miniature heater by modulating the lithium-water reaction kinetics using bubbles in a channel. Our heaters are up to 8,000 times smaller than current devices and can provide precise (within 5 °C) and tunable heating from 37 °C to 65 °C (?TRT = 12 °C to 40 °C) with ramp-up times of a minute. We demonstrate field portablity and stability and show their use in an electricity-free multistep workflow that needs a range of temperatures. Ultimately, we envision providing better access to cutting edge biochemical techniques, including diagnostics, by making portable and electricity-free heating available at any location.

SUBMITTER: Udugama B 

PROVIDER: S-EPMC7060698 | biostudies-literature | 2020 Mar

REPOSITORIES: biostudies-literature

altmetric image

Publications

Tunable and precise miniature lithium heater for point-of-care applications.

Udugama Buddhisha B   Kadhiresan Pranav P   Chan Warren C W WCW  

Proceedings of the National Academy of Sciences of the United States of America 20200218 9


Point-of-care diagnostic assays often involve multistep reactions, requiring a wide range of precise temperatures. Although precise heating is critical to performing these assays, it is challenging to provide it in an electricity-free format away from established infrastructure. Chemical heaters are electricity-free and use exothermic reactions. However, they are unsuitable for point-of-care multistep reactions because they sacrifice portability, have a narrow range of achievable temperatures, a  ...[more]

Similar Datasets

| S-EPMC3115660 | biostudies-literature
| S-EPMC10265040 | biostudies-literature
| S-EPMC4746634 | biostudies-literature
| 2219690 | ecrin-mdr-crc
| S-EPMC8250055 | biostudies-literature
| S-EPMC8382230 | biostudies-literature
| S-EPMC9018536 | biostudies-literature
| S-EPMC8433387 | biostudies-literature
| S-EPMC4771446 | biostudies-other
| S-EPMC7039232 | biostudies-literature