Ontology highlight
ABSTRACT:
SUBMITTER: Trevisan M
PROVIDER: S-EPMC7063531 | biostudies-literature | 2020
REPOSITORIES: biostudies-literature
Trevisan Marta M Masi Giulia G Palù Giorgio G
Translational gastroenterology and hepatology 20200405
Liver has a central role in protein and lipid metabolism, and diseases involving hepatocytes have often repercussions on multiple organs and systems. Hepatic disorders are frequently characterized by production of defective or non-functional proteins, and traditional gene therapy approaches have been attempted for years to restore adequate protein levels through delivery of transgenes. Recently, many different genome editing platforms have been developed aimed at correcting at DNA level the defe ...[more]