Ontology highlight
ABSTRACT:
SUBMITTER: Nakanishi H
PROVIDER: S-EPMC7064597 | biostudies-literature | 2020 Mar
REPOSITORIES: biostudies-literature
Nakanishi Hideyuki H Saito Hirohide H
Nature communications 20200310 1
Synthetic RNA-based gene circuits enable sophisticated gene regulation without the risk of insertional mutagenesis. While various RNA binding proteins have been used for translational repression in gene circuits, the direct translational activation of synthetic mRNAs has not been achieved. Here we develop Caliciviral VPg-based Translational activator (CaVT), which activates the translation of synthetic mRNAs without the canonical 5'-cap. The level of translation can be modulated by changing the ...[more]