Ontology highlight
ABSTRACT:
SUBMITTER: Kespohl M
PROVIDER: S-EPMC7065878 | biostudies-literature | 2020 Mar
REPOSITORIES: biostudies-literature
Kespohl Meike M Bredow Clara C Klingel Karin K Voß Martin M Paeschke Anna A Zickler Martin M Poller Wolfgang W Kaya Ziya Z Eckstein Johannes J Fechner Henry H Spranger Joachim J Fähling Michael M Wirth Eva Katrin EK Radoshevich Lilliana L Thery Fabien F Impens Francis F Berndt Nikolaus N Knobeloch Klaus-Peter KP Beling Antje A
Science advances 20200311 11
Protein modification with ISG15 (ISGylation) represents a major type I IFN-induced antimicrobial system. Common mechanisms of action and species-specific aspects of ISGylation, however, are still ill defined and controversial. We used a multiphasic coxsackievirus B3 (CV) infection model with a first wave resulting in hepatic injury of the liver, followed by a second wave culminating in cardiac damage. This study shows that ISGylation sets nonhematopoietic cells into a resistant state, being indi ...[more]