Ontology highlight
ABSTRACT:
SUBMITTER: Perng YC
PROVIDER: S-EPMC7097117 | biostudies-literature | 2018 Jul
REPOSITORIES: biostudies-literature
Perng Yi-Chieh YC Lenschow Deborah J DJ
Nature reviews. Microbiology 20180701 7
The host response to viral infection includes the induction of type I interferons and the subsequent upregulation of hundreds of interferon-stimulated genes. Ubiquitin-like protein ISG15 is an interferon-induced protein that has been implicated as a central player in the host antiviral response. Over the past 15 years, efforts to understand how ISG15 protects the host during infection have revealed that its actions are diverse and pathogen-dependent. In this Review, we describe new insights into ...[more]