Ontology highlight
ABSTRACT:
SUBMITTER: Ramezani-Rad P
PROVIDER: S-EPMC7065954 | biostudies-literature | 2020 Mar
REPOSITORIES: biostudies-literature
Ramezani-Rad Parham P Leung Charlotte R CR Apgar John R JR Rickert Robert C RC
Journal of immunology (Baltimore, Md. : 1950) 20200131 6
Mature naive B cells expressing BCRs of the IgM and IgD isotypes respond to Ag in secondary lymphoid organs. However, the vast majority of B cells do not undergo productive Ag encounter and have finite life spans dependent on survival signals propagated by the BCR and the BAFFR. In this study, we show that the E3 ubiquitin ligase Fbw7 is required for the maintenance of mature B cell populations in mice. BCR stimulation of B cells induced substantial apoptosis along with proliferative and growth ...[more]