Variable prediction accuracy of polygenic scores within an ancestry group.
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ABSTRACT:
SUBMITTER: Mostafavi H
PROVIDER: S-EPMC7067566 | biostudies-literature | 2020 Jan
REPOSITORIES: biostudies-literature
Publications
Variable prediction accuracy of polygenic scores within an ancestry group.
Mostafavi Hakhamanesh H Harpak Arbel A Agarwal Ipsita I Conley Dalton D Pritchard Jonathan K JK Przeworski Molly M
eLife 20200130
Fields as diverse as human genetics and sociology are increasingly using polygenic scores based on genome-wide association studies (GWAS) for phenotypic prediction. However, recent work has shown that polygenic scores have limited portability across groups of different genetic ancestries, restricting the contexts in which they can be used reliably and potentially creating serious inequities in future clinical applications. Using the UK Biobank data, we demonstrate that even within a single ances ...[more]
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