Theoretical and empirical quantification of the accuracy of polygenic scores in ancestry divergent populations.
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ABSTRACT:
SUBMITTER: Wang Y
PROVIDER: S-EPMC7395791 | biostudies-literature | 2020 Jul
REPOSITORIES: biostudies-literature
Publications
Theoretical and empirical quantification of the accuracy of polygenic scores in ancestry divergent populations.
Wang Ying Y Guo Jing J Ni Guiyan G Yang Jian J Visscher Peter M PM Yengo Loic L
Nature communications 20200731 1
Polygenic scores (PGS) have been widely used to predict disease risk using variants identified from genome-wide association studies (GWAS). To date, most GWAS have been conducted in populations of European ancestry, which limits the use of GWAS-derived PGS in non-European ancestry populations. Here, we derive a theoretical model of the relative accuracy (RA) of PGS across ancestries. We show through extensive simulations that the RA of PGS based on genome-wide significant SNPs can be predicted a ...[more]
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