Ontology highlight
ABSTRACT:
SUBMITTER: Cao F
PROVIDER: S-EPMC7070051 | biostudies-literature | 2020 Mar
REPOSITORIES: biostudies-literature
Cao Fakun F Zhou Yuhuan Y Liu Xiaoting X Yu Cheng-Han CH
Communications biology 20200313 1
Integrin receptors orchestrate cell adhesion and cytoskeletal reorganization. The endocytic mechanism of integrin-β3 receptor at the podosome remains unclear. Using viscous RGD-membrane as the model system, here we show that the formation of podosome-like adhesion promotes Dab2/clathrin-mediated endocytosis of integrin-β3. Integrin-β3 and RGD ligand are endocytosed from the podosome and sorted into the endosomal compartment. Inhibitions of podosome formation and knockdowns of Dab2 and clathrin r ...[more]