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Allosteric GABAA Receptor Modulators-A Review on the Most Recent Heterocyclic Chemotypes and Their Synthetic Accessibility.

ABSTRACT: GABAA receptor modulators are structurally almost as diverse as their target protein. A plethora of heterocyclic scaffolds has been described as modulating this extremely important receptor family. Some made it into clinical trials and, even on the market, some were dismissed. This review focuses on the synthetic accessibility and potential for library synthesis of GABAA receptor modulators containing at least one heterocyclic scaffold, which were disclosed within the last 10 years.

SUBMITTER: Vega Alanis BA

PROVIDER: S-EPMC7070463 | biostudies-literature | 2020 Feb

REPOSITORIES: biostudies-literature

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Allosteric GABAA Receptor Modulators-A Review on the Most Recent Heterocyclic Chemotypes and Their Synthetic Accessibility.

Vega Alanis Blanca Angelica BA Iorio Maria Teresa MT Silva Luca L LL Bampali Konstantina K Ernst Margot M Schnürch Michael M Mihovilovic Marko D MD

Molecules (Basel, Switzerland) 20200224 4

GABAA receptor modulators are structurally almost as diverse as their target protein. A plethora of heterocyclic scaffolds has been described as modulating this extremely important receptor family. Some made it into clinical trials and, even on the market, some were dismissed. This review focuses on the synthetic accessibility and potential for library synthesis of GABAA receptor modulators containing at least one heterocyclic scaffold, which were disclosed within the last ...[more]

PMID: 32102309

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